Identification of human herpesvirus 6 latency-associated transcripts.
نویسندگان
چکیده
Four kinds of latency-associated transcripts of human herpesvirus 6 were identified which were detected only in latently infected cells. Although they were oriented in the same direction as the immediate-early 1 and 2 (IE1/IE2) genes and shared their protein-coding region with IE1/IE2, their transcription start sites and exon(s) were latency associated.
منابع مشابه
Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6.
Latency-associated transcripts of human herpesvirus 6 (H6LTs) (K. Kondo et al. J. Virol. 76:4145-4151, 2002) were maximally expressed at a fairly stable intermediate stage between latency and reactivation both in vivo and in vitro. H6LTs functioned as sources of immediate-early protein 1 at this stage, which up-regulated the viral reactivation.
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عنوان ژورنال:
- Journal of virology
دوره 76 8 شماره
صفحات -
تاریخ انتشار 2002